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邵敬伟
来源:未知 作者:admin 更新时间:2018-10-09
 
姓名: 邵敬伟
学历: 博士
职称: 教授
职务: 福州大学肿瘤转移预警与预防研究所副所长
E-mail: shaojingwei@fzu.edu.cn
研究方向:
肿瘤防治相关药物研发及药理机制、纳米药物载体与靶向治疗
招生专业:药剂学、生物化工
教育经历:

1999/09-2004/06 沈阳农业大学,食品科学学院,博士
1995/09-1999/07 大连轻工业学院,食品与生物工程学院,学士
工作经历:
2015/01-2016/02 美国华盛顿大学,药学院,访问学者
2013/07-至今 福州大学,化学化工学院药物化学与生物制药系,教授
2013/11-2014/02 香港大学,李嘉诚医学院生物化学系,访问学者
2011/06-2012/06 美国阿肯色州医科大学,医学院,访问学者
2007/09-2013/06 福州大学,化学化工学院药物化学与生物制药系,副教授
2004/09-2007/09 福州大学,化学化工学院药物化学与生物制药系,讲师
学术兼职:
美国药学会(AAPS) 会员并兼任美国药学会药物设计和开发委员会委员,福建省药理学会理事。
科研项目:
1. 熊果酸对肝癌细胞与血管内膜粘附的干预作用及其机制研究 国家自然科学基金面上项目(81472767,2015-2018) 
2. 预防肝癌复发转移:熊果酸对肝癌细胞粘附作用干预的分子机制 研究福建省自然科学基金面上项目(2014J01364,2014-2016) 
3. 雷公藤内酯醇控释纳米涂膜剂治疗皮肤鳞癌及其作用机制的研究 国家卫计委共建科学研究基金项目 (WKJ-FJ-15,2013-2016) 
4. 熊果酸抗肿瘤转移作用机制研究 中国博士后科学基金特别资助项目(2013T60638,2013—2015) 
5. 叶酸靶向的熊果酸衍生物抗癌活性比较研究及其作用机制探讨。国家自然科学基金青年基金项目(81201709,2013—2015) 
6. 熊果酸哌嗪衍生物-叶酸复合物靶向抗癌活性及机制研究。中国博士后科学基金面上项目(2012M511441,2012—2014) 
7. 低毒性纳米荧光标记物研究及在肿瘤细胞成像和检测。福州大学博士后启动基金(600565,2011—2013) 
8. 熊果酸及其衍生物对人肿瘤细胞凋亡诱导作用及机理研究。福建省教育厅科技项目A类(JA08004,2008-2010) 
9. “福大赛因”对人肿瘤细胞凋亡诱导作用及机理研究。福州大学科技发展基金(2009-XQ-12,2009-2011) 
10. 熊果酸及其衍生物对人肿瘤细胞凋亡诱导作用及机理研究。福建省科技厅青年科技人才创新项目(2007F0347,2007-2009) 
11. 转录与分泌水平双重调控突变胰岛素原表达的研究。福建省教育厅科技项目B类(JB05020,2005-2007) 
12. 用人PXR报告基因试验研究抗肿瘤药物的CYP3A4调节机制。福州大学校人才基金项目(HX2005-32,2005-2008) 
近5年发表的期刊论文:

[1] Shao J, Kraft JC, Li B, Yu J, Freeling JP, Koehn J, Ho RJY*, Ho. Nanodrug formulations to enhance HIV drug exposure in lymphoid tissues and cells: clinical significance and potential impact on treatment and eradication of HIV/AIDS. Nanomedicine, doi: 10.2217/nnm.16.1,2016.
[2] Wan L, Dong H, Xu H, Ma J, Zhu Y, Lu Y, Wang J, Zhang T, Li T, Xie J, Xu B, Xie F, Gao Y, Shao J, Tu X, Jia L. Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. Oncotarget, 6(34): 35157-35172,2015.
[3] Xiang L, Chi T, Tang Q, Yang X, Ou M, Chen X, Yu X, Chen J, Ho RJY, Shao J*, Jia L. A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. Oncotarget, 6(11): 9295,2015.
[4] Ho RJY, Yu J, Li B, Kraft JC, Freeling JP, Koehn J, Shao J. Systems Approach to targeted and long acting HIVAIDS therapy. Drug delivery and translational research, 5(6): 531-539,2015.
[5] Li Y, Zeng R, Chen J, Wu Y, Chou G, Gao Y, Shao J, Cai H, Jia L. Pharmacokinetics and metabolism study of isoboldine, a major bioactive component from Radix Linderae in male rats by UPLC-MS/MS. Journal of ethnopharmacology, 171: 154-160, 2015.
[6] Yang X, Zhao W, Hu X, Hao X, Hong F, Wang J, Xiang L, Zhu Y, Yuan Y, Ho RJ, Wang W*, Shao J*. Synthesis, characterization and anticancer activity of novel lipophilic emodin cationic derivatives. Chemical biology & drug design, 86(6): 1451-1457, 2015.
[7] Yang X, Li Y, Jiang W, Ou M, Chen Y, Xu Y, Wu Q, Zheng Q, Wu F, Wang L, Zou W, Zhang YJ, Shao J*. Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs. Chemical biology & drug design, 86(6): 1397-1404,2015.
[8] Lu Y, Liang H, Yu T, Xie J, Chen S, Dong H, Sinko PJ, Lian S, Xu J, Wang J, Yu S, Shao J, Yuan B, Wang L, Jia L*. Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry. Cancer, 121(17): 3036-3045,2015.
[9] Xie J, Gao Y, Zhao R, Sinko PJ, Gu S, Wang J, Li Y, Lu Y, Yu S, Wang L, Chen S, Shao J, Jia L*. Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials. Journal of Controlled Release, 209: 159-169, 2015.
[10] Xie J, Lu Y, Dong H, Zhao R, Chen H, Shen W, Sinko PJ, Zhu Y, Wang J, Shao J*, Gao Y, Xie F, Jia L*. Enhanced Specificity in Capturing and Restraining Circulating Tumor Cells with Dual Antibody-Dendrimer Conjugates. Advanced Functional Materials, 25(8): 1304-1313, 2015.
[11] Zeng R, Li Y, Chen J*, Chou G, Gao Y, Shao J, Jia L, Wu S, Wu S. A novel UPLC-MS/MS method for sensitive quantitation of boldine in plasma, a potential anti-inflammatory agent: application to a pharmacokinetic study in rats. Biomedical Chromatography, 29(3): 459-464, 2015.
[12] Gao Y*, Li Z, Xie X, Wang C, You J, Mo F, Jin B, Chen J, Shao J, Chen H, Jia L*. Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: Synthesis and biological evaluation. European Journal of Pharmaceutical Sciences, 70: 55-63, 2015.
[13] Yu S, Yang X, Zhu Y, Xie F, Lu Y, Yu T, Yan C, Shao J, Gao Y, Mo F, Cai G, Sinko P, Jia L*. Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex. Scientific reports, 5, 7830; dio: 10.1038/srep07830, 2015.
[14] Dong H#, Yang X#, Xie J, Xiang L, Li Y, Ou M, Chi T, Liu Z, Yu S, Gao Y, Chen J, Shao J*, Jia L*. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochemical Pharmacology, 93(2): 151-162, 2015.
[15] Xie J, Zhao R, Gu S, Dong H, Wang J, Lu Y, Sinko PJ, Yu T, Xie F, Wang L, Shao J*, Jia L*. The Architecture and Biological Function of Dual Antibody-Coated Dendrimers: Enhanced Control of Circulating Tumor cells and Their Hetero-Adhesion to Endothelial Cells for Metastasis Prevention. Theranostics, 4(12): 1250, 2014.
[16] Wang J, Jiang Z, Xiang L, Li Y, Ou M, Yang X, Shao J*, Lu Y, Lin L, Chen J , Dai Y, Jia L*. Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis, Scientific reports, 4, 5006; doi: 10.1038/srep05006, 2014.
[17] Wang J, Chen J, Wan L, Shao J*, Lu Y, Zhu Y, Ou M, Yu S, Chen H, Jia L*, Synthesis,    spectral characterization, and in vitro cellular activities of metapristone, a potential cancer metastatic chemopreventive agent derived from mifepristone (RU486). The AAPS journal, 16(2): 289-298, 2014.
[18] Jiang X, Zhang H, Wu J, Yang X, Shao J*, Qiu B*, Lin Z, Chen G. G-quadruplex DNA biosensor for sensitive visible detection of genetically modified food, Talanta, 128: 445-449, 2014.
[19] Liang K, Zhai S, Zhang Z, Fu X, Shao J*, Lin Z, Qiu B*, Chen G. Ultrasensitive colorimetric carcinoembryonic antigen biosensor based on hyperbranched rolling circle amplification, Analyst, 139(17): 4330-4334, 2014.
[20] Sun N, Guo Q, Shao J*, Qiu B*, Lin Z, Wong K, Chen G. A signal-on fluorescence biosensor for detection of adenosine triphosphate based on click chemistry, Analytical Methods, 6(10): 3370-3374, 2014.
[21] Chen J, Wang J, Zeng R, Gao Y, Xu J, Zhu Y, Shao J, Jia L*. A novel UPLC/MS/MS method for rapid determination of metapristone in rat plasma, a new cancer metastasis chemopreventive agent derived from mifepristone (RU486). Journal of pharmaceutical and biomedical analysis, 95: 158-163, 2014.
[22] Lu Y, Yu T, Liang H, Wang J, Xie J, Shao J*, Gao Y, Yu S, Chen S, Wang L, Jia L*. Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade. Scientific Reports, 4 , 4344; doi: 10.1038/srep04344, 2014.
[23] Jiang Z#, Shao J# Yang T, Wang J, Jia L*. Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy. Journal of pharmaceutical and biomedical analysis, 87: 98-104, 2014.
[24] Chen J, Wang J, Shao J, Gao Y, Xu J, Yu S, Liu Z, Jia L*, The Unique Pharmacological Characteristics of Mifepristone: from Terminating Pregnancy to Preventing Cancer Metastasis. Medicinal research reviews, 34(5): 979-1000, 2014.
[25] Gao Y#, Shao J#, Jiang Z, Chen J, Gu S, Yu S, Zheng K, Jia L*, Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug discovery today, 19(3): 326-340, 2014
[26] Gao Y, Xie J, Chen H, Gu S, Zhao R, Shao J, Jia L*, Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnology advances, 32(4): 761-777, 2014.
[27] Shao J, Jia L*. Potential serious interactions between nutraceutical ginseng and warfarin in patients with ischemic stroke. Chinese medicine, 16: 2924-2942, 2013.
[28] Shao J, Robert J, Ekaterina I, Kim J, Nathan K, Jessica W, Thikra M, Alexandru B, Dmitry A, Zharov VP*. Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics. Scientific Reports, 3, 1293; doi: 10.1038/srep01293, 2013.
[29] Shao J, Dai Y, Zhao W, Xie J, Jia L*. Intracellular distribution and mechanisms of actions of photosensitizer Zinc (II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells. Cancer letters, 330(1): 49-56, 2013.
[30] Xie J#, Shao J#, Lu Y, Chen J, Wang J, Yu S, Jia L*. Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy. Current drug metabolism, 14(5): 616-623, 2013.
[31] Wang W*, Zhang F, Zhao W, Bai Z, Yang H, Shao J, YuanY. The synthesis, structural study and anticancer activity evaluation of emodin derivatives containing conjugative groups. Medicinal Chemistry, 9(4): 545-552, 2013.
[32] Jiang Z#, Shao J#, Chen M, Wang J, Jia L*. A novel SPE-HPLC method for simultaneous determination of selected sulfonated phthalocyanine zinc complexes in mouse plasma following cassette dosing. Analyst, 138(15): 4385-4392, 2013.
[33] Jia L*, Lu Y, Shao J, Liang X, Xu Y*. Nanoproteomics: a new spin from emerging links between nanotechnology and proteomics. Trends in biotechnology, 31(2): 99-107, 2013.
[34] Dong Y, Pang H, Yang H, Guo C, Shao J, Chi Y, Li C*, Yu T*. Carbon-based dots co-doped with nitrogen and sulfur for high quantum yield and excitation-independent emission. Angewandte Chemie International Edition 52(30): 7800-7804, 2013.
[35] Shao J, Xue J, Dai Y, Liu H, Chen N*, Jia L*, Huang J. Inhibition of human hepatocellular carcinoma HepG2 by phthalocyanine photosensitiser PHOTOCYANINE: ROS production, apoptosis, cell cycle arrest. European Journal of Cancer, 48(13): 2086-2096, 2012.
[36] Shao J, Zhang F, Bai Z, Wang C, Yuan Y, Wang W*. Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives. European journal of medicinal chemistry, 56: 308-319, 2012.
[37] Shao J, Lin M, Li Y, Li X, Liu J, Liang J, Yao H*. In vivo blood glucose quantification using raman spectroscopy. PloS one, 7(10): e48127, 2012.
[38] Shao J, Yao H*, Meng L, Li Y, Lin M, Li X, Liu J, Liang J. Raman spectroscopy of circulating single red blood cells in microvessels in vivo. Vibrational Spectroscopy, 63: 367-370, 2012.
[39] Wang W, Bai Z, Zhang F, Wang C, Yuan Y, Shao J*. Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents. European journal of medicinal chemistry, 56: 320-331, 2012.
[40] Dong Y, Shao J, Chen C, Li H, Wang R, Chi Y*, Lin X, Chen G. Blue luminescent graphene quantum dots and graphene oxide prepared by tuning the carbonization degree of citric acid. Carbon, 50(12): 4738-4743, 2012.
[41] Zhang F, Xue J, Shao J, Jia L*. Compilation of 222 drugs’ plasma protein binding data and guidance for study designs. Drug discovery today, 17(9): 475-485, 2012.
[42] Dong Y, Wang R, Li H, Shao J, Chi Y*, Lin X, Chen G. Polyamine-functionalized carbon quantum dots for chemical sensing. Carbon, 50(8): 2810-2815, 2012.
[43] Shao J*, Dai Y, Xue J, Wang J, Lin F, Guo Y. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. European journal of medicinal chemistry, 46(7): 2652-2661, 2011.
授权的发明专利:
[1] 邵敬伟,向利平. 一种熊果酸衍生物在制备预防和治疗肿瘤转移药物中的应用,2015.12,中国,专利授权号:ZL201410189256.1
[2] 王文峰,邵敬伟. 具有抗癌活性的大黄素双链双季铵盐及其制备方法,2015.10,中国,专利授权号:ZL201410620217.2
[3] 邵敬伟,向利平. 一种芦荟大黄素季铵盐及其制备和应用,2015.4,中国,专利授权号:ZL201410176299.6
[4] 邵敬伟,李园芳. 一种具有抗癌效果的组合物,2015.1, 中国,专利授权号:ZL201310053667.3
[5] 王文峰,邵敬伟. 一种具有抗癌活性的单羟基大黄素二正辛基季铵盐,2014.7, 中国,专利授权号:ZL201110135298.3
[6] 邵敬伟,王文峰. 具有抗癌活性的羟基全保护的双癸基季铵盐及其制备方法,2013.8,中国,专利授权号:ZL201010295815
[7] 王文峰,邵敬伟. 具有抗癌活性的β-羟基保护的双癸基季铵盐及其制备方法,2013.4,中国,专利授权号:ZL201010295813
[8] 邵敬伟, 林凤屏. 一种具有抗肿瘤活性的熊果酸哌嗪类衍生物及其制备方法,2012.4,中国,专利授权号:ZL 201010240154.X
 
 

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